RxSelect: Student Pharmacist

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December 2023 : Does finerenone improve kidney and cardiovascular outcomes in patients with diabetic kidney disease? Discusses randomized studies, inclusion criteria, composite end points, run-in period, event driven trial, bias, study power, and type I and II error.
November 2023 : Is semaglutide effective for overweight or obese adults? Discusses randomized studies, inclusion criteria, baseline characteristics, generalizability of study results, intention-to-treat analysis, multiple comparisons, and type I error.
October 2023 : Does sacubitril/valsartan improve outcomes in patients with heart failure with preserved ejection fraction? Discusses randomized clinical trials, active control, run-in period, inclusion and exclusion criteria, generalizability of study results, composite end point, hierarchical statistical analysis, type I and II error, exploratory findings, and subgroup analysis.
September 2023: Is acetaminophen use safe during pregnancy? Discusses expert consensus statements, grading the strength of evidence, conflicts of interest, panel representation, and applicability of recommendations in day-to-day practice.
August 2023 : Does intranasal tranexamic acid reduce the need for intranasal packing in patients with a nosebleed? Does intranasal tranexamic acid reduce the need for intranasal packing in patients with a nosebleed?
July 2023 : Should you consider testosterone therapy for men with low testosterone due to aging? Discusses criteria for developing or evaluating practice guidelines, grading strength of evidence, conflicts of interest, guideline panel representation, feasibility of interventions in day-to-day practice, and prospective guideline validation.
June 2023 : What is the impact of giving oral iron every other day versus a standard regimen? Discusses open-label study design, generalization of results, intention to treat analysis, loss to follow-up, continuous variables, nonparametric tests, treatment adherence.
May 2023 : Does taking blood pressure medications at bedtime reduce cardiovascular risk? Discusses PROBE study design, investigator bias, generalizability of trial results, study validity, absolute risk versus relative risk, multiple comparisons, and type I error.
April 2023 : How should you manage acute and recurrent gout? Discusses criteria for developing or evaluating practice guidelines, grading strength of evidence, conflicts of interest, guideline panel representation, feasibility of interventions in day-to-day practice, and prospective guideline validation.
March 2023 : Does SMART therapy improve outcomes in patients with persistent asthma? Discusses systematic review and meta-analysis, guidelines for reporting and evaluating meta-analyses, composite end points, generalizability, heterogeneity, and random versus fixed effects analysis.
February 2023 : Do omega-3 fatty acids with EPA and DHA reduce cardiovascular events in high-risk patients? Discusses randomized controlled trials, inclusion and exclusion criteria, considerations with the choice of a placebo, composite outcomes, event-driven study, generalizability of results, study, power, type II error.
January 2023 : How effective is baloxavir versus placebo or oseltamivir to improve symptoms due to influenza? Discusses inclusion and exclusion criteria, generalizability of trail results, subgroup analysis, multiple comparison, and type I and II error..
December 2022 : What should you recommend to treat head lice? Discusses criteria for developing or evaluating practice guidance, grading strength of evidence, conflicts of interest, feasibility of interventions in day-to-day practice, and prospective validation.
November 2022 : What is the risk of gallbladder or biliary disease with GLP-1 receptor agonists? Discusses systematic review and meta-analysis, guidelines for reporting and evaluating meta-analyses, validity, strength of evidence, and study heterogeneity.
October 2022 When is the onset of acute kidney injury most likely with “triple whammy” drugs? Discusses database studies, association versus causation, study power, type II error, confounders, and reporting bias.
September 2022 Are proton pump inhibitors safe and effective for patients with coronary artery disease? Discusses systematic review and meta-analysis, guidelines for reporting and evaluating meta-analyses, study quality and heterogeneity, strength of evidence, and publication bias.
August 2022: What is the impact of using nonrecommended direct oral anticoagulant doses in patients with atrial fibrillation? Discusses cohort study design, observational studies, association versus causation, misclassification bias, confounders, and STROBE guidelines.
July 2022: How should you manage medications in patients with nonalcoholic fatty liver disease (NAFLD)? Discusses criteria for developing or evaluating practice guidelines, grading strength of evidence, conflicts of interest, guideline panel representation, feasibility of interventions in day-to-day practice, and prospective guideline validation. What are the new guidelines for management of nonalcoholic fatty liver disease (NAFLD)?
June 2022: Is regular phosphodiesterase 5 inhibitor use associated with serious ocular side effects? Discusses nested case-control study design, controls, matching, administrative databases, misclassification bias, exposure misclassification, sensitivity analysis, and STROBE guidelines. Is a shorter course of antibiotics effective for community-acquired pneumonia in children?
May 2022: How should you manage medications in patients with heart failure with reduced ejection fraction? Discusses criteria for developing or evaluating practice guidelines, grading strength of evidence, conflicts of interest, guideline panel representation, feasibility of interventions in day-to-day practice, and prospective guideline validation.
April 2022: Does acetaminophen increase blood pressure in patients with hypertension? Discusses crossover studies, study design, generalization of study results, analysis of paired data, inclusion and exclusion criteria, and per-protocol analysis.
March 2022: Is a shorter course of antibiotics effective for community-acquired pneumonia in children? Discusses randomized studies, inclusion and exclusion criteria, generalization of study results, DOOR and RADAR, intention-to-treat analysis, and study validity.
February 2022: How should you manage antiplatelet meds after a coronary stent? Discusses criteria for developing or evaluating practice guidelines, grading strength of evidence, conflicts of interest, guideline panel representation, feasibility of interventions in day-to-day practice, and prospective guideline validation.
January 2022: How should you manage benign prostatic hyperplasia (BPH)? Discusses criteria for developing or evaluating practice guidelines, grading strength of evidence, conflicts of interest, guideline panel representation, feasibility of interventions in day-to-day practice, and prospective guideline validation.
December 2021: Does methylphenidate decrease apathy in patients with Alzheimer disease? Discusses randomized studies, inclusion and exclusion criteria, generalization of study results, statistical versus clinical significance, “spin” in result reporting.

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